Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-κB and MAP kinase

Figure 1 Effects of AH6809 or NG-Nitro-L-arginine Methyl Ester on lipopolysaccharide-induced action in interstitial cells of Cajal. A: Pacemaker currents of interstitial cells of Cajal (ICCs) at a holding potential of -70 mV in control condition; B: Pacemaker currents of ICCs incubated at 37 °C with 200 μg/mL of lipopolysaccharide (LPS) for 12 h; C: Pacemaker currents in ICCs pretreated with AH6809 (10 μmol/L) for 2 h prior to LPS incubation; D: Pacemaker currents in ICCs pretreated with NG-Nitro-L-arginine Methyl Ester (10 μmol/L) for 2 h prior to LPS incubation. LPS: Lipopolysaccharide; L-NAME: NG-Nitro-L-arginine Methyl Ester.