NAFLD fibrosis score: A prognostic predictor for mortality and liver complications among NAFLD patients

Table 6 Multivariate logistic regression model showing OR (95%CI) for predictors for death in 302 patients with nonalcoholic fatty liver disease

Multivariate analysis	P value	OR	95%CI
Model 1
Presence of new-onset CHD	< 0.0001	9.0	2.9-28.4
NFS at baseline	< 0.0001	1.9	1.4-2.6
Use of metformin	0.02	0.2	0.04-0.8
Use of simvastatin	0.001	0.05	0.01-0.3
Model 2
NFS changes per year	0.04	14.9	1.1-206.4
Presence of new onset of CHD	0.001	8.0	2.4-26.1
NFS at baseline	< 0.0001	2.1	1.5-2.9
Use of metformin	0.02	0.2	0.04-0.7
Use of simvastatin	0.001	0.06	0.01-0.3
Model 3
Presence of new onset of CHD	< 0.0001	9.2	2.6-32.2
NFS at baseline	< 0.0001	2.6	1.7-3.9
Use of metformin	0.03	0.2	0.04-0.8
Use of simvastatin	0.001	0.03	0.003-0.2
Interaction between NFS	0.004	0.06	0.008-0.4
at baseline and NFS
change per year
NFS changes per year	0.6	2.2	0.07-67.8

Model 1 without interaction among 9 included variables: gender, systolic blood pressure, diastolic blood pressure, nonalcoholic fatty liver disease (NAFLD) fibrosis score at baseline, use of metformin, use of simvastatin, use of aspirin, presence of new-onset of coronary heart disease (CHD) and new onset of liver complications; Model 2 without interaction among 10 included variables: gender, systolic blood pressure, diastolic blood pressure, NAFLD fibrosis score (NFS) at baseline, NFS changes per year, use of metformin, use of simvastatin, use of aspirin, presence of new-onset coronary heart disease (CHD) and new onset of liver complications; Model 3 added variables of interaction between NFS at baseline and NFS changes per year, interaction among use of aspirin, metformin, aspirin and simvastatin into model 2.