Risk factors for hepatic decompensation in patients with primary biliary cirrhosis

Table 4 Univariate analysis of possible risk factors for hepatic decompensation in primary biliary cirrhosis

	Decompensation free (n = 196)	Decompensation (n = 62)	P value
Age at diagnosis (yr)	50.2	55.6	< 0.001
Gender (female/male)	178/18	59/3	0.275
Symptoms	60.20%	80.65%	0.003
UDCA treatment	85.20%	30.65%	< 0.001
ANA	64.80%	80.65%	0.019
AMA	92.86%	95.16%	0.731
ACA	19.39%	56.45%	< 0.001
ALT (IU/L)	89.6	96.6	0.109
AST (IU/L)	80.6	103.2	< 0.001
AST/ALT	1.05	1.27	0.013
ALP (IU/L)	311.6	454.1	< 0.001
GGT (IU/L)	395.4	524.3	0.001
ALB (g/L)	41.5	38.4	< 0.001
TBil (μmol/L)	20.92	48.84	< 0.001
DBil (μmol/L)	9.27	29.06	< 0.001
IgG (g/L)	16.61	17.43	0.386
IgA (g/L)	2.99	3.62	0.004
IgM (g/L)	4.61	4.83	0.285
Histological stage1 (I-II)	92.22%	66.67%	0.008
Early PBC	9.70%	0.00%	0.023
Extra-hepatic autoimmune disease	37.24%	37.10%	0.983

¹n = 108. ANA: Anti-nuclear antibody; AMA: Anti-mitochondrial antibody; ACA: Anti-centromere antibody; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; GGT: γ-glutamyl-transferase; ALB: Albumin; TBil: Total bilirubin; DBil: Direct bilirubin; UDCA: Ursodeoxycholic acid; Ig: Immunoglobulin.