What is the role of adiponectin in obesity related non-alcoholic fatty liver disease?

Figure 1 Summary of multiple signaling pathways that mediate the anti-steatotic effects of adiponectin. HMW: High molecular weight; AdipoR: Adiponectin receptor; APPL1: Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; AMPK: AMP-activated kinase; ACC: Acetyl Coenzyme A carboxylase; CPT1: Carnitine palmitoyl transferase 1; SREBP1: Sterol regulatory element-binding protein 1; FAS: Fatty acid synthase; GPAT: Glycerol-3-phosphate acyltransferase; ACOX: Acyl-CoA oxidase; LCAS: Long chain acyl-CoA synthetase; FATP: Fatty acid transport protein; PPARα: Peroxisome proliferator-activated receptor α; TG: Triacylglyceride; FA: Fatty acid.