Novel CDH1 germline mutations identified in Chinese gastric cancer patients

Table 1 Frequency distributions of variables in gastric cancer cases and controls n (%)

Variables	Cases	Controls	P value
Number	236	240
Age (yr)			0.997
≤ 49	19 (8.1)	19 (7.9)
50-59	65 (27.5)	65 (27.1)
60-69	94 (39.8)	98 (40.8)
≥ 70	58 (24.6)	58 (24.2)
Gender			0.915
Male	178 (75.4)	180 (75.0)
Female	58 (24.6)	60 (25.0)
Family history
Familial recurrence for gastric cancer1	6 (2.5)
Low familial recurrence for gastric cancer2	39 (16.5)
Young age (< 50 yr) of sporadic disease	16 (6.8)
Old age (≥ 50 yr) of sporadic disease	175 (74.2)
Histologic grade3
Poorly differentiated adenocarcinoma	64 (39.5)
Moderately differentiated adenocarcinoma	69 (42.6)
Well differentiated adenocarcinoma	29 (17.9)
Depth invasion (pT)34
pT1	12 (7.4)
pT2	32 (19.8)
pT3	109 (67.3)
pT4	9 (5.5)
Lymph node involvement (pN)34
pN0	35 (21.6)
pN1	3 (1.9)
pN2	65 (40.1)
pN3	59 (36.4)
Distant metastasis (M)34
M0	161 (99.4)
M1	1 (0.6)
TNM stage34
Stage I	8 (4.9)
Stage II	39 (24.1)
Stage III	115 (71.0)

¹Individuals with gastric cancer and two or more first-degree relatives with gastric cancer or related cancers;

²Individuals with gastric cancer and one first-degree relative with gastric cancer or related cancers;

³Available for 162 cases;

⁴According to the National Comprehensive Cancer Network guidelines on tumor-node-metastasis (TNM) Staging Classification for Carcinoma of the Stomach (7^th ed., 2010) by the American Joint Committee on cancer.