Probiotics increase T regulatory cells and reduce severity of experimental colitis in mice

Figure 4 Expression of cytokines in colonic mucosa. A: Level of tumor necrosis factor (TNF)-α; B: Level of interferon (IFN)-γ; C: Level of interleukin (IL)-2; D: Level of IL-4; E: Level of IL-10. Normal: In the normal group, the animals were administrated with physiological saline; Model: In the model group, the animals were challenged with 2,4,6-trinitrobenzene sulfonic acid (TNBS) without treatment; Bifico: In the Bifico group, the animals were challenged by TNBS and treated with Bifico at 345 mg/kg; Mesalazine: In the Mesalazine group, the animals were challenged by TNBS and treated with 300 mg/kg Mesalazine. Data are the means ± SE (n = 10). ^aP < 0.05, ^bP < 0.01 vs the normal group; ^cP < 0.05, ^dP < 0.01 vs the model group.