Desferrioxamine in warm reperfusion media decreases liver injury aggravated by cold storage

Figure 5 Relationship between presence of iron and liver damage. Following ischemia: A: The relationships between lactate dehydrogenase (LDH) and iron in the absence of desferrioxamine (DFO) (circles) and the presence of DFO (crosses) were described by y = 327x - 5 (n = 19, r² = 0.84) and y = 162x + 6 (n = 14, r² = 0.69) respectively; B: The relationships between aspartate aminotransferase (AST) and iron in the absence of DFO (circles) and the presence of DFO (crosses) were described by y = 52x - 0.9 (n = 19, r² = 0.81) and y = 33x + 1 (n = 14, r² = 0.44); C: During perfusion, samples collected at 0.5 h, 1 h, 1.5 h and 2 h were analysed. The relationships between LDH and iron in the absence of DFO (circles) and the presence of DFO (crosses) were described by y = 487x - 8.1 (n = 76, r² = 0.88) and y = 291x - 24.4 (n = 56, r² = 0.91) respectively; D: The relationships between AST and iron in the absence of DFO (circles) and the presence of DFO (crosses) were described by y = 81x - 0.5 (n = 76, r² = 0.90) and y = 62x - 5.6 (n = 56, r² = 0.80) respectively. All correlation coefficients were significant (P < 0.05), and all slopes for media containing iron were significantly different (P < 0.05) from the equivalent treatment without DFO.