Desferrioxamine in warm reperfusion media decreases liver injury aggravated by cold storage

Figure 2 The effect of desferrioxamine added during cold storage, warm ischemia and/or perfusion on liver function following 20 h of cold storage. A,B: Desferrioxamine was added (indicated by +) to cold storage (CS), warm ischemia and perfusion media. Liver damage was assessed by measuring lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) in media from livers during perfusion at 1 and 2 h; C, D: Liver health was assessed by liver swelling (liver wet to dry ratio) after 2 h of perfusion and bile flow over 2 h of perfusion. Data for extended (20 h) CS are shown. Significantly different from 20 h of CS (mean ± SE, n = 5, ^aP < 0.05).