Effectiveness of a hydroxynaphthoquinone fraction from Arnebia euchroma in rats with experimental colitis

Figure 4 Hydroxynaphthoquinone mixture decreases myeloperoxidase activity (A) and serum tumor necrosis factor-α level (B) in rats with 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Colitis was induced by intracolonic administration of TNBS (80 mg/kg, dissolved in 50% ethanol). Rats were treated daily for 7 d with HM (2.5, 5, 10 mg/kg) and mesalazine 100 mg/kg 24 h after TNBS instillation. TNF-α level was determined by ELISA. Data are represented as mean ± SD of 8 animals of each group. ^bP < 0.01 vs control; ^cP < 0.05, ^dP < 0.01 vs TNBS alone. HM: Hydroxynaphthoquinone mixture; TNBS: 2,4,6-trinitrobenzene sulfonic acid; MPO: Myeloperoxidase; TNF-α: Tumor necrosis factor-α.