Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India

Figure 2 Phylogenetic relationships among complete preS1/pre S2/S sequences (nt 2854-835 numbering according to GenBank accession AY233274). A: Subgenotype A1 from hepatitis B virus (HBV) positive patients from Kerala (marked in bold) compared with sequences obtained from GenBank established using the neighbor joining method; B: Genotype D isolates from HBV positive patients from Kerala (marked in bold) compared with HBV isolates obtained from GenBank established using the neighbor joining method. Bootstrap statistical analysis was performed using 1000 replicates. Each sequence obtained from GenBank is designated by its accession number and its country of origin. The characteristic amino acids in the preS1 and polymerase spacer regions are indicated next to the sequences or relevant clades.