TNF-α-308 polymorphism and risk of digestive system cancers: A meta-analysis

Table 2 Stratified analysis of the tumor necrosis factor alpha polymorphism and digestive system cancers risk

Group	GA + AA vs GG			GA vs GG			AA vs GG			AA vs GA + GG
	n	OR (95%CI)	P1	n	OR (95%CI)	P1	n	OR (95%CI)	P1	n	OR (95%CI)	P1
Overall	58	1.23 (1.09, 1.38)2	< 0.00001	52	1.14 (1.01, 1.28)2	< 0.00001	44	1.43 (1.19, 1.73)	0.26	44	1.38 (1.15, 1.66)	0.55
Studies with HWE	46	1.18 (1.03, 1.34)2	< 0.00001	46	1.14 (1.00, 1.29)2	< 0.00001	38	1.54 (1.25, 1.90)	0.15	38	1.48 (1.20, 1.81)	0.40
Cancer type
Gastric	28	1.23 (1.12, 1.34)2	0.009	27	1.15 (1.04, 1.27)	0.07	22	1.38 (1.06, 1.80)	0.63	22	1.33 (1.03, 1.72)	0.67
Colorectal	10	1.17 (0.87, 1.57)2	< 0.0001	10	1.10 (0.83, 1.45)2	0.0004	9	1.45 (0.76, 2.75)2	0.02	9	1.40 (0.99, 2.00)	0.07
Hepatocellular	15	1.74 (1.20, 2.54)2	< 0.00001	10	1.58 (1.05, 2.39)2	0.002	8	2.55 (1.38, 4.70)	0.49	8	2.15 (1.19, 3.90)	0.66
Pancreatic	3	1.04 (0.79, 1.36)	0.94	3	1.04 (0.79, 1.38)	0.88	3	0.99 (0.46, 2.14)	0.63	3	0.99 (0.46, 2.13)	0.60
Esophageal	2	0.82 (0.58, 1.16)	0.89	2	0.80 (0.55, 1.15)	0.89	2	1.01 (0.42, 2.43)	0.95	2	1.05 (0.44, 2.51)	0.92
Ethnicity
Asian	27	1.24 (0.99, 1.56)2	< 0.00001	25	1.07 (0.94, 1.22)2	0.008	19	1.55 (1.11, 2.17)	0.43	19	1.47 (1.05, 2.06)	0.60
Caucasian	31	1.21 (1.05, 1.40)2	< 0.00001	27	1.17 (1.01, 1.35)2	< 0.0001	25	1.38 (1.10, 1.74)	0.18	25	1.34 (1.08, 1.67)	0.39

¹Test for heterogeneity;

²Random-effects model was used when the P for heterogeneity test was < 0.05. GG: Guanine/Guanine; GA: Guanine/Adenine; AA: Adenine/Adenine; HWE: Hardy-Weinberg equilibrium.