Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis

Table 5 Genetic polymorphisms in Hereditary Haemochromatosis patients grouped according the presence or absence of advanced fibrosis and subjected to univariate analysis n (%)

Gene	No/minimal fibrosis (F0-2)	Advanced fibrosis (F3-4)	P value
MCP1
AA	99 (53.5)	28 (46.7)
AG	76 (41.1)	27 (45.0)
GG	10 (5.4)	5 (8.3)	0.546
CCR2
GG	142 (78.0)	50 (84.8)
AG	37 (20.3)	9 (15.3)
AA	3 (1.7)	0 (0)	0.401
TGFβ
GG	154 (83.2)	51 (85)
GC	31 (16.8)	9 (15)	0.749
hOGG1
CC	99 (53.8)	26 (43.3)
CG	64 (34.8)	25 (41.7)
GG	21 (11.4)	9 (15)	0.352
IL10-1082
GG	50 (27.1)	17 (28.3)
GA	97 (52.4)	33 (55.0)
AA	38 (20.5)	10 (16.7)	0.806
IL10-592
CC	120 (64.9)	37 (61.7)
AC	58 (31.3)	17 (28.3)
AA	7 (3.8)	6 (10.0)	0.173
TLR4 299
AA	159 (86.4)	54 (91.5)
AG	24 (13.0)	4 (6.8)
GG	1 (0.6)	1 (1.7)	0.305
TLR4 399
CC	161 (87.0)	53 (89.8)
CT	23 (12.4)	5 (8.5)
TT	1 (0.5)	1 (1.7)	0.502

MCP-1: Monocyte chemoattractant protein 1; CCR-2: Chemokine C-C motif receptor; IL10: Interleukin-10; TGF-β: Transforming growth factor-beta; TLR4: Toll-like receptor 4; hOGG1: Human 8-oxoguanine DNA glycosylase.