Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis

Table 3 Patient characteristics grouped according to the presence or absence of hepatic fibrosis (univariate analysis) n (%)

Parameter	No fibrosis (n = 136)	Fibrosis present (n = 109)	P value
Male gender	72 (53)	89 (82)	0.0001
Age at biopsy (yr) (mean ± SD)	39.7 (14.9)	44.3 (12.4)	0.006
Alcohol (g/d) (median: range)	5 (0-120)	20 (0-200)	0.0001
Steatosis present1	36 (37)	42 (53)	0.03
Serum ferritin (μg/L) (median: range)	531 (33-3000)	2134 (155-6000)	0.0001
HIC (μmol/g dw) (median: range)	124 (20-537)	218 (43-847)	< 0.0001
Iron grade
0	1 (1)	0
1	5 (4)	0
2	27 (20)	7 (6)
3	63 (46)	25 (23)
4	40 (29)	77 (71)	< 0.0001

¹Steatosis data available for 176 subjects (72% of total cohort).