Anti-miRNA-221 sensitizes human colorectal carcinoma cells to radiation by upregulating PTEN

doi:10.3748/wjg.v19.i48.9307

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Dec 28, 2013 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2013; 19(48): 9307-9317
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9307

Table 2 Impact of PTEN on miR-221-mediated Caco2 cell radiosensitivity

Group	D₀	D_q	SF₄	SER
Blank control + irradiation	1.677	5.590	0.5667
Anti-PTEN-siRNA + irradiation	2.327	7.788	0.7569	0.718
Anti-miR-221 + irradiation	1.082	4.702	0.2977	1.550
Anti-miR-221 and anti-PTEN-siRNA + irradiation	1.511	5.010	0.4788	1.110

Caco2 cells were pretreated with anti-PTEN-siRNA for 24 h prior to the addition of anti-miR-221. D₀ and D_q were determined by standardized software, and the sensitization enhancement ratio (SER) was calculated by determining the ratio of the D₀ of the control group vs treated cells. SF₄: Surviving fraction at 4 Gy.

Citation: Xue Q, Sun K, Deng HJ, Lei ST, Dong JQ, Li GX. Anti-miRNA-221 sensitizes human colorectal carcinoma cells to radiation by upregulating PTEN. World J Gastroenterol 2013; 19(48): 9307-9317
URL: https://www.wjgnet.com/1007-9327/full/v19/i48/9307.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i48.9307