Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India

doi:10.3748/wjg.v19.i48.9294

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2013; 19(48): 9294-9306
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9294

Table 3 Summary of the pre-S mutations prevalent among the three clinical groups and genotypes

Isolate	Age/sex	Clinicalstatus	Subgenotype	PreS1	PreS2					Functionsaffected
				Start codon	Nucleotide from the EcoRI start			Amino acids from preS2 start codon
					Start codon	Deletion size	Position	Deletion size	Position
CHB42	40/M	CH	A1	ATG	ACG	-	-	-	-		A
HCC12	60/M	HCC	A1	ATG	ACG	-	-	-	-	A
HCC25	50/M	HCC	A1	ATG	ACG	-	-	-	-	A
CHB137	16/F	CH	A1	Deletion	ATG	18	2854-2871	6	1-6	I
CHB170	29/F	CH	D2	ATG	ATG	21	35-55	7	16-22	T, B, P
CHB202	33/M	CH	A1	ATG	ATG	24	28-51	8	13-21	T, B, P
CHB413	35/M	CH	A1	ATG	ATG	6	49-54	2	21-22	B, P
HCC29	50/F	HCC	A1	ATG	ATA	33	22-54	11	11-22	A, T, B, P
HCC30	32/M	HCC	A1	ATG	ATG	24	30-53	8	13-21	T, B, P
HCC37	30/F	HCC	A1	ATG	ATG	33	24-56	11	11-22	T, B, P
HCC39	55/M	HCC	A1	ATG	ATG	33	24-56	11	11-22	T, B, P
HCCT3	38/M	HCC	A1	ATG	ATA	54	1-54	18	4-22	A, T, B, P, M

A: PreS2 initiation codon abolished; M1T, M1I; I: PreS1 initiation start codon abolished; M: Morphogenesis domain ps1:103-119 and ps2: 1-4; T: T cell epitope ps1: 109-119/ps2: 1-13; B: B cell epitope, amino acids 14-26; P: Putative neutralizing anti-preS2 antibody, amino acids 1-26; HCC: Hepatocellular carcinoma; CHB: Chronic hepatitis B.

Citation: Gopalakrishnan D, Keyter M, Shenoy KT, Leena KB, Thayumanavan L, Thomas V, Vinayakumar K, Panackel C, Korah AT, Nair R, Kramvis A. Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India. World J Gastroenterol 2013; 19(48): 9294-9306
URL: https://www.wjgnet.com/1007-9327/full/v19/i48/9294.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i48.9294