Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India

doi:10.3748/wjg.v19.i48.9294

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2013; 19(48): 9294-9306
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9294

Table 2 Multiple logistic regression analysis of basal core promoter/precore region in different disease groups

		HCC		Non HCC (CR/CH)		OR (95%CI)	P value
		Gen A (n = 20)	Gen D (n = 6)	Gen A (n = 26)	Gen D (n = 11)
Basic core promoter/ pre core region	A1762T/G1764A + G1764A only	16 (80)	5 (83)	14 (54)	3 (27)	20.2 (6.3-65)^a	0.008^aNS^d
	C1766T/T1768A	9 (45)	1 (5)	5 (25)	0	25 (7.3-86)^a 14.3 (1.7–119)^d	0.03^a0.05^d
	1773T (genotype A)	19 (95)	-	25	-
	1773C (genotype D)	-	4	-	7	-	NS^a
	G1862T	18 (90)	2 (33)	21 (81)	1(9)	30.33 (5.62-192.6)^d	NS^a 0.0001^d
	G1896A	0	4 (67)	0	2 (18)	-	NS^a 0.0002^c
	A1762T/G1764A + G1862T	13 (65)	1 (2)	13 (50)	0	4.81 (0.6-39.4)^b	NS^a 0.0004^b
Complete S region	Pre-S deletions	5 (33.3)^e	0	3 (17.6)	1 (9)	1.89 (0.54-6.60)^b	NS^bNS^d

^aComparison between hepatocellular carcinoma (HCC) and non-HCC, all genotypes;

^bComparison between HCC and non-HCC, restricted to genotype A isolates;

^cComparison between HCC and non-HCC, restricted to genotype D isolates;

^dComparison between genotype A and D isolates;

^ePercentage out of 15 genotype A HCC isolates that were sequenced in the S region. CR: Cirrhosis; CH: Chronic hepatitis.

Citation: Gopalakrishnan D, Keyter M, Shenoy KT, Leena KB, Thayumanavan L, Thomas V, Vinayakumar K, Panackel C, Korah AT, Nair R, Kramvis A. Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India. World J Gastroenterol 2013; 19(48): 9294-9306
URL: https://www.wjgnet.com/1007-9327/full/v19/i48/9294.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i48.9294