Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India

doi:10.3748/wjg.v19.i48.9294

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2013; 19(48): 9294-9306
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9294

Table 1 Demographic, clinical and virological characteristics of hepatitis B surface antigen-positive patients with different disease profiles

	Characteristic	Group I HCC (n = 44)	Group II CR (n = 22)	Group III CH (n = 25)	Total (n = 91)
Demographic and clinical data	Gender (M/F)	33/11	18/4	18/7	69/22
	Age (yr) (mean ± SD)	48.70 ± 10.94^a	40.68 ± 11.52	26.28 ± 11.10	40.87 ± 14.66
	ALT, IU/L	73.50 ± 11.65	70.50 ± 41.09	56.32 ± 30.01	67.45 ± 37.74
	HBeAg positive¹	7 (24.14)	4 (14.3)	9 (37.5)	20 (26.67)
Virological characteristics	HBV DNA log₁₀ copies/mL¹	4.79 ± 1.41^a	3.38 ± 1.69	3.27 ± 2.12	4.03 ± 1.83
	Number genotyped by direct sequencing/RFLP	21/19	9/12	19/6	86
	Genotype A	33 (82.5)^a	14 (66.6)	15 (60)	62 (72.1)
	Subgenotype A1	30	14	15	59 (95)
	Subgenotype A2	3	-	-	3 (5)
	Genotype C	-	1 (4.8)	-	1 (1.2)
	Genotype D	7 (17.5)	6 (28.6)	10 (40)	23 (26.7)
	Subgenotype D1²	-	1	3
	Subgenotype D2	4	2	6
	Subgenotype D3	1	-	-

^aP < 0.05 vs chronic hepatitis.

¹Depletion of serum allowed the viral loads to be determined for only 28, and hepatitis B e antigen for 29 HCC sera;

²Subgenotyping of genotype D was performed by direct sequencing. CH: Chronic hepatitis; HCC: Hepatocellular carcinoma; CR: Cirrhosis; SD: Standard deviation; ALT: Alanine aminotransferase; RFLP: Restriction fragment length polymorphism; HBeAg: Hepatitis B e antigen.

Citation: Gopalakrishnan D, Keyter M, Shenoy KT, Leena KB, Thayumanavan L, Thomas V, Vinayakumar K, Panackel C, Korah AT, Nair R, Kramvis A. Hepatitis B virus subgenotype A1 predominates in liver disease patients from Kerala, India. World J Gastroenterol 2013; 19(48): 9294-9306
URL: https://www.wjgnet.com/1007-9327/full/v19/i48/9294.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i48.9294