Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus

Table 4 Univariate and multivariate Cox regression analyses of patient and tumour factors with disease free survival for patients undergoing neoadjuvant chemotherapy (n = 136)

		Univariate			Multivariate
		HR	95%CI	Pvalue	HR	95%CI	Pvalue
Patient factors
Age		0.972	(0.944-1.00)	0.054
Sex	Female	1.000	Ref
	Male	0.953	(0.453-2.005)	0.899
ASA	1	1.000	Ref
	2	0.696	(0.313-1.548)	0.374
	3	0.947	(0.352-2.546)	0.914
Performance status	0	1.000	Ref
	1	1.016	(0.578-1.789)	0.955
	2	0.950	(0.218-4.129)	0.945
O-POSSUM
Tumour response
TRG	1	1.000	Ref
	2	1.099	(0.099-12.148)	0.939
	3	8.404	(1.071-65.929)	0.043
	4	7.829	(1.054-58.163)	0.044
	5	15.422	(2.083-114.189)	0.007
TRG grouped	1-2	1.000	Ref		1.000	Ref
	3-5	9.504	(2.973-30.380)	< 0.0001	6.315	(1.261-31.616)	0.025
Lymph node response
Lymph nodes downstaged	Yes	1.000	Ref		1.000	Ref
	No	5.784	(3.064-10.919)	< 0.0001	6.161	(1.683-22.554)	0.006
Tumour factors
ypT stage	0	1.000	Ref		1.000	Ref
	1	2.085	(0.232-18.711)	0.512	0.281	(0.020-3.928)	0.345
	2	5.214	(0.687-39.549)	0.110	0.286	(0.022-3.705)	0.338
	3	9.490	(1.293-69.635)	0.027	0.469	(0.034-6.460)	0.571
	4	52.907	(6.008-465.873)	< 0.0001	1.519	(0.087-26.389)	0.774
ypN stage	0	1.000	Ref		1.000	Ref
	1	4.791	(2.434-9.431)	< 0.0001	0.476	(0.133-1.700)	0.253
	2	4.102	(2.005-8.392)	< 0.0001	0.254	0.070-0.927)	0.038
	3	7.449	(3.522-15.756)	< 0.0001	0.476	(0.129-1.755)	0.265
ypM stage	0	1.000	Ref		1.000	Ref
	1	3.172	(1.253-8.031)	0.015	2.693	(0.924-7.847)	0.069
Vascular invasion	No	1.000	Ref		1.000	Ref
	Yes	3.444	(2.080-5.702)	< 0.0001	1.929	(1.034-3.600)	0.039
Lymphatic invasion	No	1.000	Ref		1.000	Ref
	Yes	2.201	(1.268-3.821)	0.005	1.253	(0.637-2.462)	0.514
Perineural invasion	No	1.000	Ref		1.000	Ref
	Yes	5.073	(2.896-8.886)	< 0.0001	2.766	(1.444-5.300)	0.002
Resection clearance	R0	1.000	Ref		1.000	Ref
	R1	3.869	(2.272-6.588)	< 0.0001	1.805	(0.940-3.468)	0.076

TRG: Tumour Regression Grade; ASA: American Society of Anesthesiologists classification; O-POSSUM: Oesophagogastric surgery-physiological and operative severity score for the enumeration of mortality and morbidity.