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World J Gastroenterol. Dec 28, 2013; 19(48): 9256-9270
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9256
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9256
Table 1 Pharmacokinetics parameters in healthy volunteers after administration of curcuminphytosomes or unformulated curcumin
Curcuminoid | Formulation | AUC (ng/mL) | Cmax (ng/mL) | tmax (h) | Relative absorption2 |
Curcumin (1a) | Curcuminphytosome high | 538.0 ± 130.7 | 50.3 ± 12.7 | 3.8 ± 0.6 | 19.21 |
Curcuminphytosome low | 272.6 ± 68.52 | 24.2 ± 5.9 | 4.2 ± 0.8 | 17.53 | |
Reference | 122.5 ± 29.3 | 9.0 ± 2.8 | 6.9 ± 2.2 | 1 | |
Demethoxycurcumin (1b) | Curcuminphytosome high | 655.0 ± 195.7 | 134.6 ± 40.6 | 2.4 ± 0.3 | 68.34 |
Curcuminphytosome low | 297.4 ± 107.3 | 39.1 ± 11.4 | 3.1 ± 0.4 | 55.54 | |
Reference | 55.8 ± 15.5 | 4.2 ± 1.1 | 4.4 ± 1.0 | 1 | |
Bisdemethoxycurcumin (1c) | Curcuminphytosome high | 142.2 ± 58.2 | 24.9 ± 8.1 | 2.2 ± 0.4 | 56.85 |
Curcuminphytosome low | 70.1 ± 34.3 | 8.8 ± 3.1 | 2.4 ± 0.6 | 53.15 | |
Reference | 24.6 ± 10.3 | 2.1 ± 0.8 | 3.4 ± 1.2 | 1 | |
Total curcuminoids | Curcuminphytosome high | 1336.0 ± 357.1 | 206.9 ± 54.9 | 2.7 ± 0.3 | 31.56 |
Curcuminphytosome low | 640.2 ± 197.7 | 68.9 ± 16.9 | 3.3 ± 0.3 | 27.26 | |
Reference | 202.8 ± 53.8 | 14.4 ± 4.2 | 6.9 ± 2.2 | 1 |
- Citation: Dulbecco P, Savarino V. Therapeutic potential of curcumin in digestive diseases. World J Gastroenterol 2013; 19(48): 9256-9270
- URL: https://www.wjgnet.com/1007-9327/full/v19/i48/9256.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i48.9256