Hepatitis C virus protease inhibitor-resistance mutations: Our experience and review

doi:10.3748/wjg.v19.i47.8940

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World Journal of Gastroenterology

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World J Gastroenterol. Dec 21, 2013; 19(47): 8940-8948
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8940

Table 1 Overview of representative clinical trials of hepatitis C virus NS3/4A protease inhibitors

Name of drug (other name)	G	Trial phase	Features of clinical trials (ClinicalTrials.gov Identifier)
Telaprevir (VX-950)	1	FDA approved	Telaprevir, PEG-IFN alpha-2a, RBV
	1b	3	Telaprevir, Daclatasvir (NS5A inhibitor), PEG-IFN alpha-2a, RBV (COMMAND-3) (NCT01492426)
	1	3	Telaprevir, PEG-IFN lambda-1a, RBV (NCT01598090)
	4	2	Telaprevir, PEG-IFN alpha-2a, RBV (NCT0050801)
Boceprevir	1	FDA approved	Boceprevir, PEG-IFN alpha-2a, RBV
(SCH 503034)Simeprevir (TMC435)	1	3	Simeprevir, PEG-IFN alpha-2a, RBV (NCT01290731)
(SCH 503034)Simeprevir (TMC435)	1b/4	2	Simeprevir, IDEX719 (NS5A inhibitor), RBV (NCT01852604)
Faldaprevir (BI201335)	1	3	Faldaprevir, PEG-IFN alpha-2a, RBV
	1a	2	Faldaprevir, PPI-668 (NS5A inhibitor), BI207127 (non-nucleoside NS5B inhibitor), (+ RBV) (NCT01859962)
	1b	2	Faldaprevir, BI207127, RBV (NCT01858961)
Danoprevir (ITMN-191)	1	2	Danoprevir, PEG-IFN alpha-2a, RBV (NCT00963885)
	1/4	2	Danoprevir, Ritonavir, PEG-IFN alpha-2a, RBV (NCT01220947)
	1	2	Danoprevir, Ritonavir, RO5024048 (NS5B inhibitor), RBV, (± PEG-IFN alpha-2a) (NCT01331850)
Vaniprevir (MK-7900)	1	3	Vaniprevir, PEG-IFN alpha-2b, RBV (NCT01405937)
Asunaprevir (BMS-650032)	1	3	Asunaprevir, Daclatasvir (NCT01497834)
	1	2	Asunaprevir, PEG-IFN lambda, RBV (NCT01309932)
	1/4	2	Asunaprevir, PEG-IFN alpha-2a, RBV (NCT01030432)
	1a/1b/4	2	Asunaprevir, Daclatasvir, BMS-791325 (NS5B inhibitor) (NCT01455090)

Data from http://www.clinicaltrials.gov accessed on September 8, 2013. FDA: United States Food and Drug Administration; G: Genotype; HCV: Hepatitis C virus; PEG-IFN: Peginterferon; RBV: Ribavirin.

Citation: Wu S, Kanda T, Nakamoto S, Imazeki F, Yokosuka O. Hepatitis C virus protease inhibitor-resistance mutations: Our experience and review. World J Gastroenterol 2013; 19(47): 8940-8948
URL: https://www.wjgnet.com/1007-9327/full/v19/i47/8940.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i47.8940