Intestinal stem cell marker LGR5 expression during gastric carcinogenesis

doi:10.3748/wjg.v19.i46.8714

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2013; 19(46): 8714-8721
Published online Dec 14, 2013. doi: 10.3748/wjg.v19.i46.8714

Table 2 Association of immunodetected LGR5 expression with clinicopathological features of gastric cancer patients n (%)

Clinicopathological feature	LGR5 expression		P value
Clinicopathological feature	Negative	Positive
Sex			P value	0.072
Male	56 (43.1)	74 (56.9)
Female	29 (58.0)	21 (42.0)
Age, yr			0.005
≤ 60	48 (58.5)	34 (41.5)
> 60	37 (37.8)	61 (62.2)
Location in stomach			0.657
Upper	15 (40.5)	22 (59.5)
Mid	17 (47.2)	19 (52.8)
Lower	45 (49.5)	46 (50.5)
Lesion size in cm			0.612
≤ 4	33 (42.9)	44 (57.1)
> 4	32 (47.1)	36 (52.9)
Differentiation			0.006
Differentiated	31 (36.5)	54 (63.5)
Undifferentiated	54 (56.8)	41 (43.2)
Histological type			0.579
Adenocarcinoma	67 (46.2)	78 (53.8)
Others	18 (51.4)	17 (48.6)
Lauren type			0.035
Intestinal	48 (41.4)	68 (58.6)
Diffuse/other	37 (57.8)	28 (42.2)
Lymphovascular invasion			0.288
No	43 (43.9)	55 (56.1)
Yes	42 (51.9)	39 (48.1)
Depth			0.833
T1-T2	19 (48.7)	20 (51.3)
T3-T4	66 (46.8)	75 (53.2)
Lymph node metastasis			0.934
No	19 (47.5)	21 (52.5)
Yes	65 (46.8)	74 (53.2)
Metastasis			0.160
No	71 (45.2)	86 (54.8)
Yes	14 (60.9)	9 (39.1)
TNM			0.046
I-II	27 (38.0)	44 (62.0)
III-IV	58 (53.2)	51 (46.8)

LGR5: Leucine-rich repeat-containing G protein-coupled receptor 5; TNM: Tumor, nodes, metastasis.

Citation: Zheng ZX, Sun Y, Bu ZD, Zhang LH, Li ZY, Wu AW, Wu XJ, Wang XH, Cheng XJ, Xing XF, Du H, Ji JF. Intestinal stem cell marker LGR5 expression during gastric carcinogenesis. World J Gastroenterol 2013; 19(46): 8714-8721
URL: https://www.wjgnet.com/1007-9327/full/v19/i46/8714.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i46.8714