Alanine aminotransferase normalization at week 8 predicts viral response during hepatitis C treatment

Table 3 Comparison of sustained virological response in patients with high and normalized alanine aminotransferase levels at week 4, 8, 12, 24, 48 and 72 in patients with and without rapid virological response

	Initial abnormal ALT level in patients		P2value	Initial abnormal ALT level in patients		P1value
	with RVR (Group 1h,n= 33)			without RVR (Group 2h,n= 49)
	Follow-up	Follow-up		Follow-up	Follow-up
	abnormal ALT	normalized ALT		abnormal ALT	normalized ALT
After 4 wk
No. of patients	18	15		29	20
SVR rate	78	87	0.525	34	40	0.701
After 8 wk
No. of patients	9	24		18	31
SVR rate	56	88	0.049	11	52	0.004
After 12 wk
No. of patients	6	27		17	32
SVR rate	50	89	0.028	12	50	0.007
After 24 wk
No. of patients	5	28		15	34
SVR rate	40	89	0.001	7	50	0.003
After 48 wk
No. of patients	4	29		17	32
SVR rate	25	90	0.006	6	53	0.001
After 72 wk
No. of patients	4	29		21	28
SVR rate	25	90	0.006	0	64	0.000

¹Student’s t test; ²Student’s χ² test. RVR: Rapid virological response; ALT: Alanine aminotransferase; SVR: Sustained virological response.