Cooperative inhibitory effect of sinomenine combined with 5-fluorouracil on esophageal carcinoma

Figure 2 Quantitative flow cytometric measurements of G₂/M arrest and apoptosis in esophageal carcinoma cells treated with sinomenine and 5-Fluorouracil alone or in combination. The density plots illustrate four cell populations (live, apoptotic, necrotic, and late apoptotic/dead) defined by their fluorescence profiles. SIN and 5-FU alone significantly induced apoptosis compared with the group control (P < 0.05), and the combined effects were stronger than those of SIN or 5-FU alone (P < 0.05). SIN: Sinomenine; 5-FU: 5-Fluorouracil.