Role of the advanced glycation end products receptor in Crohn’s disease inflammation

Figure 4 Receptor for the advanced glycation end products staining in Crohn’s disease ulcerative areas. A: Almost all cells of the epithelial compartment in close proximity to an ulceration (red arrows) proved receptor for the advanced glycation end products (RAGE)-positive (the brown cells), with the ulcer-associated cell lineage showing the highest immunoreactivity (black arrows); B and C: A detail of the epithelial cells in the crypt compartment at level of an ulceration (red arrows) showing moderate to strong RAGE-positive staining (black arrows); D: A detail of the epithelial cells of the surface compartment next to an ulceration (red arrow) showing strong RAGE immunoreactivity (black arrows) (RAGE immunoperoxidase-hematoxylin; original magnification, × 200).