Role of the advanced glycation end products receptor in Crohn’s disease inflammation

Figure 2 Receptor for the advanced glycation end products staining in Crohn’s disease and healthy mucosa. A: Almost all cells of the epithelial compartment at both crypt and surface levels showed positive immunostaining (brown cells) in a representative case of Crohn’s disease affected areas, with only a few scattered positive cells in the lamina propria (black arrows); B: The pattern of the cellular staining in the crypt zone of a representative case of Crohn’s disease affected area is shown, indicating both membranous and cytosolic distribution; C: A representative case of control mucosa is shown, with weak staining of the epithelial cells and only a few scattered positive cells in the lamina propria (receptor for the advanced glycation end products, immunoperoxidase-hematoxylin; original magnification, × 200).