Antiviral drug resistance increases hepatocellular carcinoma: A prospective decompensated cirrhosis cohort study

doi:10.3748/wjg.v19.i45.8373

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2013; 19(45): 8373-8381
Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8373

Table 2 Clinical characterizations of the enrolled patients at baseline n (%)

	DR (n = 36)	CVR (n = 162)	Control (n = 39)
Gender n (male/female)	23/13	109/53	24/15
Age, mean ± SD (yr)	56.9 ± 14.6	58.4 ± 11.2	52.2 ± 10.8
Family history of HCC	6 (16.7)	21 (12.9)	7 (17.9)
Alcohol abuse	4 (11.1)	22 (13.5)	10 (10.2)
HBeAg positive	20 (55.6)	95 (58.6)	22 (56.4)
Child-Pugh Score, mean ± SD	9.0 ± 2.8	8.6 ± 2.3	7.9 ± 2.1
qHBV DNA (log), mean ± SD	5.4 ± 2.3	4.9 ± 2.5	4.9 ± 1.7
PTINR, mean ± SD	1.98 ± 0.87	2.24 ± 1.29	2.03 ± 1.16
BUN, mean ± SD (mmol/L)	8.3 ± 3.7	9.1 ± 4.2	8.0 ± 2.5
Cr, mean ± SD (μmol/L)	87.6 ± 39.3	77.4 ± 45.8	74.8 ± 20.4
Ascites	21 (58.3)	90 (55.6)	20 (51.3)
Encephalopathy	0 (0)	2 (1.2)	1 (2.6)
Variceal bleeding	17 (47.2)	85 (52.4)	18 (46.1)

SD: Standard deviation; HCC: Hepatocellular carcinoma; DR: Drug-resistant; CVR: Complete virologic response; BUN: Blood urea nitrogen; Cr: Creatinine; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen.

Citation: Li L, Liu W, Chen YH, Fan CL, Dong PL, Wei FL, Li B, Chen DX, Ding HG. Antiviral drug resistance increases hepatocellular carcinoma: A prospective decompensated cirrhosis cohort study. World J Gastroenterol 2013; 19(45): 8373-8381
URL: https://www.wjgnet.com/1007-9327/full/v19/i45/8373.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i45.8373