Clinical significance of serum procalcitonin in patients with ulcerative colitis

Table 2 Sensitivity and specificity of procalcitonin and C-reactive protein for severe ulcerative colitis detection

Marker	Sensitivity	95%CI	Specificity	95%CI
Procalcitonin (ng/mL)
> 0.0250	100%	59.04-100.0	27.27%	6.022-60.97
> 0.0400	100%	59.04-100.0	72.73%	39.03-93.98
> 0.0550	100%	59.04-100.0	100%	71.51-100.0
> 0.0650	71.43%	29.04-96.33	100%	71.51-100.0
> 0.0850	57.14%	18.41-90.10	100%	71.51-100.0
> 0.1050	42.86%	9.899-81.59	100%	71.51-100.0
> 0.1150	28.57%	3.669-70.96	100%	71.51-100.0
> 0.1350	14.29%	0.3610-57.87	100%	71.51-100.0
C-reactive protein (mg/dL)
> 0.2500	100%	59.04-100.0	27.27%	6.022-60.97
> 0.5000	85.71%	42.13-99.64	36.36%	10.93-69.21
> 0.7000	85.71%	42.13-99.64	45.45%	16.75-76.62
> 0.9000	85.71%	42.13-99.64	63.64%	30.79-89.07
> 1.400	85.71%	42.13-99.64	72.73%	39.03-93.98
> 2.600	85.71%	42.13-99.64	81.82%	48.22-97.72
> 3.600	85.71%	42.13-99.64	90.91%	58.72-99.77
> 4.050	71.43%	29.04-96.33	90.91%	58.72-99.77
> 4.700	71.43%	29.04-96.33	100%	71.51-100.0
> 7.100	57.14%	18.41-90.10	100%	71.51-100.0
> 9.850	42.86%	9.899-81.59	100%	71.51-100.0
> 10.75	28.57%	3.669-70.96	100%	71.51-100.0
> 11.35	14.29%	0.3610-57.87	100%	71.51-100.0
> 11.35	14.29%	0.3610-57.87	100%	76.84-100.0

A procalcitonin cut-off value of 0.055 ng/mL had good diagnostic accuracy for detecting severe ulcerative colitis, as demonstrated by the sensitivity (100%; 95%CI: 59.04-100.0) and specificity (100%; 95%CI: 71.51-100.0) (Table 2). Moreover, at a cut-off level of C-reactive protein > 3.6 mg/dL, the sensitivity for detecting severe ulcerative colitis was 85.71% (95%CI: 42.13-99.64), and the specificity was 90.91% (95%CI: 58.72-99.77).