Biliary tree gastrinomas in multiple endocrine neoplasia type 1 syndrome

Table 3 Clinicopathological characteristics of multiple endocrine neoplasia type 1 patients with extraduodenal-extrapancreatic gastrinomas reported in the literature

Ref.	Sex/age	Site/size (mm)	Gastrin: basal/stimulation	Diagnostic imaging positivity	MEN1 stigmata	Surgical treatment	Metastasis	BPC gastrin
Price et al[14]	F/55	CD (CBD junction)/6 mm	4500/NR	IOUS, discovered at surgery	pHPT, PA, NF-PETs (n°21/1-6 mm)	Distal splenopancreatectomy; RFA hepatic excision BC	Liver, (solitary)	780 (2 yr) (recurrence)
Price et al[14]	F/43	CBD/15 × 12 × 1	580/4300	IOUS, discovered at surgery	pHPT, PA, NF-PET (4), DG (3/1-4 mm); GC, lipoma	PPDP; enucleation; gastric excision	Lymph nodes (CBD HA)	86 (2 yr)
Lee et al[15]	F/39	Liver (II-III seg)/16 × 15 × 0.9	447/NR	CCT, SSRS, IOUS	pHPT, PA, insulinoma	WDP; II-III liver segmentectomy	-	34 (po)

pHPT: Primary hyperparathyroidism; PA: Pituitary adenoma; DG: Duodenal gastrinoma; GC: Gastric carcinoid; WDP: Whipple’s duodenopancreatectomy; PPDP: Pylorus preserving duodenopancreatectomy; D: Duodenal; CBD: Common bile duct; CD: Cystic duct; G: Gallbladder; N: Lymph node; F: Female.