Biliary tree gastrinomas in multiple endocrine neoplasia type 1 syndrome

Table 1 Characteristics, surgical treatment and follow-up of multiple endocrine neoplasia type 1 patients with biliary gastrinomas in our series

Pt	Sex/age (yr)	MEN1 mutation	Basal gastrinemia (NV < 108 pg/mL)	Previous surgical treatment	Surgical treatment	Postoperative complications	Latest complications and adverse events	Basal serum gastrin postoperative (pg/mL)	Secretin provocative test (at follow-up)
1	F/46	Missense, Leu413Pro exon 9	213.2	Total PTX	TP and removal of a bile duct gastrinoma		Insulin-dependentdiabetes mellitusCholangitis	39.9	NEG
2	F/55	Frameshift, 843del GA, exon 6	87.1	Left nephrectomy for hydronephrosis, total PTX with autotransplantation	WDP	Pancreatojejunal dehiscence for acute pancreatitis→TP with splenectomy	Abdominal abscess	24.8	NEG
3	F/37	Arg415 exon 9stop	204.3	Less than subtotal PTX	(2010) PPDP(2012) Hepatic resection (V-VIII seg) and enucleation of a pancreatic head nodule	Biliary fistula	Subocclusion	32.4	NEG

PTX: Parathyroidectomy; TP: Total pancreatectomy; WDP: Whipple’s duodenopancreatectomy; PPDP: Pylorus preserving duodenopancreatectomy; MEN1: Multiple endocrine neoplasia type 1.