Helicobacter pylori and gastric mucosa-associated lymphoid tissue lymphoma: Recent progress in pathogenesis and management

Table 2 Groupe d’Etude des Lymphomes de l’Adulte histological grading system for post-treatment evaluation of gastric mucosa-associated lymphoid tissue lymphoma

Score	Lymphoid infiltrate	LEL	Stromal changes	Clinical significance
CR	Absent or scattered plasma cells and small lymphoid cells in the LP	Absent	Normal or empty LP and/or fibrosis	Complete remission
pMRP	Aggregates of lymphoid cells or lymphoid nodules in LP/MM and/or SM	Absent	Empty LP and/or fibrosis	Complete remission
rRD	Dense, diffuse or nodular extending around glands in the LP	Focal LEL or absent	Focal empty LP and/or fibrosis	Partial remission
NC	Dense, diffuse or nodular	Present, “may be absent”	No changes	Stable disease or progressive disease

Copie-Bergman et al[34] with modification[26]. LEL: Lymphoepithelial lesions; LP: Lamina propria; MM: Muscularis propria; SM: Submucosa; CR: Complete histological response; pMRP: Probable minimal residual disease; rRD: Responding residual disease; NC: No change.