Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 28, 2013; 19(44): 8034-8041
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.8034
Table 1 Comparison of the characteristics of severe and non-severe Clostridium difficile infection patients hospitalised in medical intensive care unit between January 2007 and December 2011
TotalSevere CDINon-severe CDIP value
n = 40n = 15n = 25
Age (yr)62.9 (55.3-72.4)59.52 (54.8-77.3)64.27 (56.1-72.2)0.99
Male gender27 (67.5)13 (86.7)14 (56.0)0.045
Origin of patient0.61
Home14 (35.0)6 (40)8 (32)
Other ward and/or other hospital26 (65.0)9 (60)17 (68)
Diagnosis at MICU admission0.39
Respiratory disease15 (37.5)3 (20)12 (48)
Septic shock12 (30.0)6 (40)6 (24)
Renal disease3 (7.5)1 (6.7)2 (8)
Gastrointestinal disease3 (7.5)1 (6.7)2 (8)
Neurological disease3 (7.5)1 (6.7)2 (8)
Other4 (10.0)3 (20)1 (4)
Clinical symptoms and biological features at diagnosis
Fever23 (57.5)8 (53.3)15 (60.0)0.75
Abdominal pain15 (37.5)7 (46.7)8 (32.0)0.35
Duration of diarrhoea (d)13.0 (8.0-19.5)18 (5-29)13 (8-17)0.38
C-reactive protein (mg/L)117 (60-193)185 (73-339)105 (39-127)0.01
Albumin count (g/L)26.0 (20.0-28.0)23 (17-27)26 (21-28)0.30
Leukocyte count (x 109/L)14.4 (9.5-21.7)17.9 (10.6-33.4)12.4 (9.0-21.1)0.17
Previous exposure to CDI risk factors within 8 wk before onset of symptoms
Hospitalisation28 (70.0)10 (66.7)18 (72.0)0.72
Exposure to PPI21 (52.5)10 (66.7)11 (44.0)0.17
Chemotherapy12 (30)5 (33.3)7 (28.0)0.72
Gastrointestinal procedures23 (57.5)9 (60.0)14 (56.0)0.80
Antibiotic treatment38 (95.0)15 (100)23 (92)0.26
Cephalosporins 3rd generation22 (55)8 (53.3)14 (56)0.87
Clindamycin2 (5)1 (6.7)1 (4)0.71
Coamoxiclav16 (40)8 (53.3)8 (32)0.18
Fluoroquinolones26 (65)13 (86.7)13 (52)0.026
Treatment0.06
No treatment5 (12.5)2 (13.3)3 (12.0)
Only metronidazole25 (62.5)6 (40)19 (76)
Only vancomycin2 (5)2 (13.3)0 (0)
Metronidazole+vancomycin8 (20)5 (33.3)3 (12.0)
Duration of hospital stay (d) and outcomes
LOS in hospital27.0 (13.5-50.8)16 (5-48)28.0 (16.0-55.5)0.26
LOS in MICU14.0 (5.0-22.8)8 (2-21)16.0 (6.0-25.5)0.27
Death in 30 d16 (40)9 (60)7 (28)0.046