Amelioration of carbon tetrachloride-induced cirrhosis and portal hypertension in rat using adenoviral gene transfer of Akt

Figure 3 Histological changes in rat with cirrhosis induced by CCl₄. Livers from rats in each experimental group were collected 8 wk after CCl₄ treatment, sectioned, and subjected to HE and van gieson staining for tissue structure and collagen deposition. While cirrhosis groups without treatment or received saline or ad-enhanced green fluorescent protein treatment show structure disruption and nodule formation as well as remarkable deposition of collagen, cirrhosis group with Akt virus transfer show well preserved tissue structure and less collagen, both of which are comparable to normal control (magnification × 100).