8-bromo-7-methoxychrysin inhibits properties of liver cancer stem cells via downregulation of β-catenin

Figure 6 Wnt3a treatment antagonized the inhibitory effects of 8-bromo-7-methoxychrysin. Wnt3a treatment resulted in an increase in the expression of β-catenin in both liver cancer stem cells (LCSCs) and parental MHCC97 cells (A) and attenuated the effects of 8-bromo-7-methoxychrysin (BrMC) on the expression of β-catenin (B) and stem cell markers (C), and self-renewal capacity (D) of LCSCs derived from the MHCC97 cell line. ^aP < 0.05 vs CD133⁺ SFCs, ^cP < 0.05 vs 0.1 μmol/L BrMC or Wnt 3a alone treated group.