Role of sirtuins in ischemia-reperfusion injury

doi:10.3748/wjg.v19.i43.7594

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Nov 21, 2013 (publication date) through Jul 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2013; 19(43): 7594-7602
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7594

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Figure 1 Protective role of sirtuin 1 during ischemia. Sirtuin 1 (SIRT1) activates adenosine monophosphate protein kinase (AMPK) as a cell response to counteract the energy deficiency. SIRT1 upregulates hypoxia-inducible factor 2α (HIF2α) and downregulates HIF1α to increase their transcriptional activity. SIRT1 upregulates peroxisome proliferator-activated receptor-γ coactivator, leading to enhancement of anti-oxidant capacity of uncoupling protein 2 (UCP2). PGC1α: Peroxisome proliferator-activated receptor-γ coactivator.

Citation: Pantazi E, Zaouali MA, Bejaoui M, Folch-Puy E, Abdennebi HB, Roselló-Catafau J. Role of sirtuins in ischemia-reperfusion injury. World J Gastroenterol 2013; 19(43): 7594-7602
URL: https://www.wjgnet.com/1007-9327/full/v19/i43/7594.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i43.7594