Curcumin protects against acetaminophen-induced apoptosis in hepatic injury

Figure 1 Curcumin treatment protects against acetaminophen-induced hepatic injury in mice. A: Serum alanine aminotransferase (ALT) levels were determined 16 h after acetaminophen injection. Data are expressed as mean ± SE; n = 10 mice per group. ^bP < 0.01 vs control; ^dP < 0.001 vs acetaminophen (APAP) + carboxymethylcellulose (CMC); B: Hematoxylin-eosin stained liver sections from animals treated with PBS, APAP + CMC and APAP + CMN (original magnification: ×100 and ×400). Severe inflammatory cell infiltration and gross necrosis of the entire centrilobular areas were obvious in APAP group, and the results were significantly ameliorated in CMN-treated animals. CMN: Curcumin.