Effect of low-dose amitriptyline on globus pharyngeus and its side effects

Table 2 Change in glasgow edinburgh throat scale score and Pittsburgh sleep quality index in patients treated with amitriptyline vs pantoprazole and incidence of side effects n (%)

Variable	AMT group	Conventional group	P value
	n = 16	n = 14
GETS score
Baseline	5.44 ± 1.63	5.71 ± 1.38	0.623
3 d	3.69 ± 1.141	5.64 ± 1.28	0.000
10 d	2 ± 1.711	5.36 ± 1.22	0.000
4 wk	1.25 ± 1.841	3.79 ± 2.331	0.002
Treatment response	12 (75)	5 (35.71)	0.004
PSQI	4.19 ± 2.07	8.5 ± 4.97	0.008
Adverse effect
Dry mouth	12 (75)	4 (28.5)	0.026
Sleepiness	11 (68.8)	2 (14.3)	0.004
Dizziness	4 (25)	1 (7.1)	0.336
Constipation	3 (18.8)	1 (7.1)	0.602
Palpitations	1 (6.3)	0 (0)	1.000
Malaise	1 (6.3)	0 (0)	1.000

¹Statistically significant difference from baseline, P < 0.05 between the two groups. AMT: Amitriptyline; GETS: Glasgow Edinburgh Throat Scale; PSQI: Pittsburgh sleep quality index.