C/EBP homologous protein deficiency aggravates acute pancreatitis and associated lung injury

Figure 1 Mice deficient in C/EBP homologous protein displayed increased serum amylase, lipase, interleukin-6, and tumor necrosis factor-α. Acute pancreatitis was induced using cerulein (Cn) and lipopolysaccharide (LPS) in Chop^-/- (KO) and wild-type (WT) mice. Serum levels of amylase (A), lipase (B), interleukin (IL)-6 (C), and tumor necrosis factor (TNF)-α (D), were detected 24 h (A-C) and 9 h (D) after induction of acute pancreatitis. Data are presented as mean ± SEM (n = 6). The data are normally distributed. ^aP < 0.05 compared with WT mice without pancreatitis; ^cP < 0.05 vs WT mice with pancreatitis.