Association between Ras association domain family 1A promoter methylation and hepatocellular carcinoma: A meta-analysis

Table 1 Characteristics of included studies in meta-analysis

Author	Year	Country/area	Race	Sample	Method	Case type	Cases (n)	Control type	Controls (n)
Chan et al[22]	2008	Hong Kong	Asian	Serum	MSRE-qPCR	HCC	63	HBV infection	63
Chang et al[23]	2008	China	Asian	Plasma	MSP	HCC	26	Liver cirrhosis	16
Maurizio et al[24]	2011	Italy	Caucasian	Whole blood	MSP	HCC	31	Liver cirrhosis/chronic hepatitis C	33/30
Mohamed et al[25]	2012	Egypt	Caucasian	Plasma	QMSP	HCC	40	HCV infection	40
Azab et al[26]	2011	Egypt	Caucasian	Whole blood	MSP	HCC	20	Liver cirrhosis	14
Zhang et al[27]	2007	Taiwan	Asian	Serum	MSP	HCC	50	HBV infection/HCV infection/coinfection	9/6/2
Huang et al[28]	2011	China	Asian	Plasma	MSRE-qPCR	HCC	72	Liver cirrhosis/chronic inactive hepatitis	25/12

MSP: Methylation-specific polymerase chain reaction (PCR); QMSP: Quantitative methylation-specific PCR; MSRE-qPCR: Methylation-sensitive endonuclease-qPCR; HCC: Hepatocellular carcinoma.