Children with celiac disease and high tTGA are genetically and phenotypically different

Table 2 Symptoms in celiac disease patients n (%)

	tTGA < 100 U/mL (n = 34)	tTGA≥100 U/mL (n = 82)	P value
Symptoms
Asymptomatic	1 (2.9)	4 (4.9)	1.000
Gastrointestinal symptoms
Any gastrointestinal symptom	33 (97.1)	62 (75.6)	0.006
Only gastrointestinal symptoms	8 (23.5)	8 (9.8)	0.074
Abdominal pain	26 (76.5)	42 (51.2)	0.012
Diarrhea	8 (23.5)	27 (32.9)	0.316
Constipation	14 (41.2)	21 (25.6)	0.096
Bloating	12 (35.3)	31 (37.8)	0.799
Nausea	6 (17.6)	3 (3.7)	0.018
Vomiting	1 (2.9)	9 (11.0)	0.277
Extraintestinal symptoms
Any extraintestinal symptom	25 (73.5)	70 (85.4)	0.132
Only extraintestinal symptoms	0 (0.0)	15 (18.3)	0.005
Fatigue	16 (47.1)	35 (42.7)	0.666
Irritability	9 (26.5)	25 (30.5)	0.665
Anorexia	13 (38.2)	32 (39.0)	0.937
Increased appetite	1 (2.9)	6 (7.3)	0.672
Joint pain	2 (5.9)	9 (11.0)	0.504
Tooth enamel defects	2 (5.9)	3 (3.7)	0.629
Aphthous stomatitis	0 (0.0)	13 (15.9)	0.010
Anaemia	4 (11.8)	27 (32.9)	0.019
Short stature (height < -2 SDS)	4 (11.8)	11 (13.4)	1.000
Low weight (< -2 SDS)	2 (5.9)	7 (8.5)	1.000

tTGA: Anti-tissue transglutaminase antibodies; SDS: Standard deviation scores.