Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection

Table 3 IFNL3 polymorphisms and insulin resistance in chronic hepatitis C

Cohorts size	Study design	HCV genotype	IFNL3 SNP	% IR	HOMA-IR	Results	Ethnicity	Ref.
434	Multi-center, retrospective	HCV-1 (n = 434)	rs12979860	50%	> 3	CC genotype associated with reduced IR	Caucasians	48
202	Prospective	HCV-1 (n = 181)	rs12979860	32.20% (65/202)	≥ 3	CC genotype associated with reduced IR	Caucasians	49
		HCV-4 (n = 21)
328	Retrospective	HCV-1 (n = 328)	rs8099917	50% (84/168) in TT genotype vs 69.7% (53/76) in TG/GG genotype	≥ 2.45 in TT genotype vs≥ 1.55 in TG/GG genotype	No differences in IFNL3 genotype distribution according to HOMA-IR	Japanese	57
240	Retrospective	HCV-1 (n = 188)	rs12979860	46% (89/193)	≥ 2	No differences in HOMA-IR levels according to IFNL3 genotypes	Caucasians	59
		HCV-2 (n = 3)
		HCV- (n = 30)
		HCV-4 (n = 19)

HCV: Hepatitis C virus; IR: Insulin resistance.