Estrogen improves the hyperdynamic circulation and hyporeactivity of mesenteric arteries by alleviating oxidative stress in partial portal vein ligated rats

Figure 1 Dose-response curves for isolated rat mesenteric arteriole contractility in response to norepinephrine at different concentrations. The dose-response curves in the four partial portal vein ligation (PPVL) groups were lowered and shifted to the right compared to the sham operation (SO) group. Treatment with estrogen (E2) reversed the curve to left, whereas ICI182, 780 decreased the response to norepinephrine of arterioles treated with E2. PLAC: Placebo.