Clinical applications of next-generation sequencing in colorectal cancers

Figure 1 A classical progression model of colorectal carcinogenesis. A classical progression model of colorectal carcinogenesis is illustrated with genes whose alterations are responsible for each of the progressive steps. The right panel shows recent next-generation sequencing-based reports of the corresponding genes. CRC: Colorectal cancer; ATM: Ataxia telangiectasia mutated.