Risk of ileal pouch neoplasms in patients with familial adenomatous polyposis

Table 1 Summary of 25 reports of ileal pouch adenomas in familial adenomatous polyposis

Ref.	Study	Year	Operation	n	Type of pouch	Findings	% of adenoma	Time to neoplasia
Beart et al[17]	Case	1982	Kock	1	Kock pouch	Tubulovillous Adenomas		6 yr
Wolfstein et al[18]	Case	1982	IAA	2	Soave	Adenomas in 2 pts		3 and 7 yr
Shepherd et al[19]	Retro	1987	IPAA	12	N	Tubular Adenoma in 2 pts	16.7
Stryker et al[20]	Case	1987	Brooke ileostomy	1	Kock pouch	Tubular Adenomas		12 yr
Nugent et al[16]	Retro	1993	IPAA	38	N	Tubular Adenoma in 5 pts	13.2	4 yr (1-7)
Bertoni[21]	Pros	1995	IAA	3	N	Tubular Adenoma in 2 pts	66.7	53.7-75.4 mo
Wu et al[22]	Pros	1998	IPAA	26	S/J-pouch 9/16, 1 N	Tubular Adenoma in 11 pts	42.3	1-14 yr
Valle et al[23]	Case	2001	IPAA	5	N	Adenomas	20	5 yr
Thompson-Fawcett et al[24]	Pros	2001	Kock 5, IPAA 28	33	N	Adenoma in 14 pts (with microadenoma 20 pts)	42.4 (60.6)	7 yr (1-19)
Parc et al[4]	Pros	2001	IPAA	85	J-pouch	30 pts (28 grossly visible, 2 microadenoma)	35.3	Cumulative risk of 7%, 35%, and 75% at 5, 10, and 15 yr
Polese et al[25]	Retro	2002	IPAA	46	S/W/J-pouch 2/1/43, Kock 4	Adenoma in 2 of 30 pts	6.7	risk of Adenoma after 8 yr; 20%, (9-11 yr)
Beveridge et al[26]	Case	2004	IPAA	2	J-pouch 1, Kock 1	2 large VA, VA		4-10 yr
Vrouenraets et al[27]	Case	2004	IPAA	1	J-pouch	Adenomas with focal severe dysplastic change		6 yr
Groves et al[28]	Pros	2005	Kock 4, IPAA 56	60	W/J-pouch 13/43, Kock 4	Mild dysplasia 23, more advanced 11	56.7	6 yr (1-17)
Nilubol et al[29]	Pros	2007	IPAA	10	N	Tubular Adenoma in 1of 9 pts	11.1	11.3 yr
Moussata et al[30]	Retro	2008	IPAA	23	N	Low-grade 16, high-grade 1	73.9	4.76 yr (1-14)
Friederich et al[31]	Pros	2008	IPAA	212	N	Adenoma 74 pts, AAP 25 pts	46.7	Cumulative risk of 16% and 42.2% at 5 and 10 yr
Schulz et al[32]	Pros	2008	IPAA	35	N	Low-grade 8	22.8	mean of 5 yr
Tajika et al[33]	Retro	2009	Kock 8, IPAA 16	24	J-pouch	16 pts, (advanced 1, carcinoma 2)	66.7	Cumulative risk of 13%, 43%, and 72% at 5, 10, and 20 yr
Kang et al[34]	Case	2010	Kock	2	Kock pouch	2 (the largest one is 15mm in size)
Banasiewicz et al[35]	Pros	2011	IPAA	165	J-pouch	Low-grade 13, high-grade 8, neoplasia 5	15.8	Cumulative risk of 50%, Low-grade at 15 yr, high-grade at 17.5 yr, neoplasia 18.5 yr
Tonelli et al[36]	Pros	2012	IPAA	69	S/J-pouch 25/29, SIMM 15	Adenoma 25 pts, carcinoma 2 pts	39.1	Cumulative risk of 28.5% at 5 yr
Makni et al[37]	Case	2012	IPAA	1	J-pouch	Adenoma and carcinoma		10 yr
Wasmuth et al[38]	Retro	2013	IPAA	61	N	14 pts	23	Estimated cumulative rate of first Adenoma diagnosed was 38%
Pommaret[39]	Retro	2013	IPAA	118	J-pouch	57 pts (12 advanced Adenomas)	48.3	15 yr

Study: Type of study; Retro: Retrospective series; Pros: Prospective series; n: Number of patients in the study; IPAA: Ileal pouch-anal anastomosis; Kock: Kock continent ileostomy; N: Not described; AV: Anal verge; pts: Patients.