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World J Gastroenterol. Jan 28, 2013; 19(4): 463-481
Published online Jan 28, 2013. doi: 10.3748/wjg.v19.i4.463
Published online Jan 28, 2013. doi: 10.3748/wjg.v19.i4.463
Table 2 Characteristics of the pharmacological agents used to achieve a moderate level of sedation in gastrointestinal endoscopy (i.v. administration)1
| Agent | Chemical structure | Molecular weight (g/moL) | Onset of action (min) | Duration of action | Elimination half-life | Metabolism/excretion |
| Midazolam | C18H13ClFN3 | 325.78 | 1.0-2.5 | 2-6 h | 1.8-6.4 h | Hepatic and intestinal; excreted in urine |
| Propofol | C12H18O | 178.27 | < 1 | 3-10 min | Triphasic: 2.2 min, 20 min, 8 h | Hepatic; excreted in urine |
| Fentanyl | C22H28N2O | 336.471 | ≤ 1.5 | 1-2 h | 2-7 h | Hepatic; excreted in urine |
| Meperidine | C15H21NO2 | 247.33 | 5 | 2-4 h | 2-7 h | Hepatic; excreted in urine |
- Citation: Triantafillidis JK, Merikas E, Nikolakis D, Papalois AE. Sedation in gastrointestinal endoscopy: Current issues. World J Gastroenterol 2013; 19(4): 463-481
- URL: https://www.wjgnet.com/1007-9327/full/v19/i4/463.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i4.463