Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis

Table 4 Allele and genotype frequencies of MIF CATT5-8 haplotypes in New Zealand Caucasian controls and inflammatory bowel disease patients

Phenotype	Genotypea			MAF	Allelic P (unadjusted)	OR (95%CI)
	5/5	5/X	X/X
Control	27 (0.050)	187 (0.350)	321 (0.600)	241 (0.225)
IBD	54 (0.055)	366 (0.375)	555 (0.569)	474 (0.243)	0.27	1.10 (0.93-1.32)
UC	24 (0.051)	172 (0.364)	277 (0.586)	220 (0.233)	0.70	1.04 (0.85-1.28)
Age at first diagnosis (yr)
< 17	0	11 (0.393)	17 (0.607)	11 (0.196)	0.61	1.04 (0.43-1.65)
17-40	10 (0.043)	91 (0.394)	130 (0.563)	111 (0.240)	0.52	1.09 (0.84-1.41)
> 40	14 (0.065)	70 (0.327)	130 (0.607)	98 (0.229)	0.88	1.02 (0.78-1.33)
Disease location
Proctitis	12 (0.073)	56 (0.341)	96 (0.585)	80 (0.244)	0.48	1.11 (0.83-1.48)
Left-sided	5 (0.040)	48 (0.387)	71 (0.573)	58 (0.234)	0.77	1.05 (0.76-1.46)
Extensive	7 (0.039)	67 (0.372)	106 (0.589)	81 (0.225)	0.99	1.00 (0.75-1.33)
CD	30 (0.063)	182 (0.555)	264 (0.555)	242 (0.254)	0.12	1.18 (0.96-1.44)
Age at first diagnosis (yr)
< 17	4 (0.073)	22 (0.400)	29 (0.527)	30 (0.273)	0.26	1.29 (0.83-2.01)
17-40	15 (0.057)	104 (0.394)	145 (0.549)	134 (0.254)	0.21	1.17 (0.92-1.49)
> 40	11 (0.070)	56 (0.357)	90 (0.573)	78 (0.248)	0.39	1.14 (0.85-1.52)
Disease location
Colonic	14 (0.070)	75 (0.375)	111 (0.555)	103 (0.258)	0.19	1.19 (0.91-1.56)
Ileocaecal	7 (0.058)	48 (0.397)	66 (0.545)	62 (0.256)	0.19	1.19 (0.86-1.64)
Ileal	9 (0.060)	56 (0.371)	86 (0.570)	74 (0.245)	0.47	1.12 (0.83-1.51)
Disease behaviour
Non-stricturing/non-penetrating	18 (0.066)	104 (0.382)	150 (0.551)	140 (0.257)	0.15	1.19 (0.94-1.51)
Penetrating	1 (0.019)	20 (0.377)	32 (0.604)	22 (0.208)	0.68	0.90 (0.55-1.47)
Stricturing	11 (0.073)	58 (0.384)	82 (0.543)	80 (0.265)	0.15	1.24 (0.93-1.66)

^aX = 6, 7, or 8 CATT repeats. IBD: Inflammatory bowel disease; UC: Ulcerative colitis; CD: Crohn’s disease.