Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis

Table 3 Allele and genotype frequencies of MIF-173G > C in New Zealand Caucasian patients with inflammatory bowel disease compared with controls

Phenotype	Genotype			MAF	Allelic P (unadjusted)	OR (95%CI)
	GG	GC	CC
Control	328 (0.672)	143 (0.293)	17 (0.035)	177 (0.181)
IBD	668 (0.676)	287 (0.290)	33 (0.033)	353 (0.179)	0.86	0.98 (0.80-1.20)
UC	320 (0.687)	129 (0.277)	17 (0.036)	163 (0.175)	0.71	0.96 (0.76-1.21)
Age at first diagnosis (yr)
< 17	17 (0.610)	11 (0.390)	0	11 (0.196)	0.78	1.10 (0.56-2.18)
17-40	153 (0.680)	60 (0.267)	12 (0.053)	84 (0.187)	0.81	1.04 (0.78-1.38)
> 40	150 (0.704)	58 (0.272)	5 (0.023)	68 (0.160)	0.33	0.86 (0.63-1.17)
Disease location
Proctitis	106 (0.658)	49 (0.304)	6 (0.037)	61 (0.189)	0.75	1.06 (0.76-1.46)
Left-sided	92 (0.742)	27 (0.218)	5 (0.040)	37 (0.149)	0.23	0.79 (0.54-1.16)
Extensive	118 (0.670)	52 (0.295)	6 (0.034)	64 (0.182)	0.99	1.00 (0.73-1.38)
CD	331 (0.669)	149 (0.301)	15 (0.030)	179 (0.181)	0.98	0.00 (0.79-1.25)
Age at first diagnosis (yr)
< 17	36 (0.642)	19 (0.339)	1 (0.017)	21 (0.188)	0.87	1.04 (0.63-1.72)
17-40	188 (0.683)	81 (0.295)	6 (0.220)	93 (0.169)	0.55	0.92 (0.70-1.21)
> 40	107 (0.652)	49 (0.299)	8 (0.049)	65 (0.198)	0.50	1.12 (0.81-1.53)
Disease location
Colonic	131 (0.633)	68 (0.328)	8 (0.039)	84 (0.203)	0.35	1.15 (0.86-1.54)
Ileocaecal	81 (0.653)	37 (0.298)	6 (0.048)	49 (0.198)	0.56	1.11 (0.78-1.58)
Ileal	115 (0.719)	44 (0.275)	1 (0.006)	46 (0.144)	0.12	0.76 (0.53-1.08)
Disease behaviour
Non-stricturing/non-penetrating	181 (0.644)	92 (0.327)	8 (0.028)	108 (0.192)	0.60	1.07 (0.82-1.40)
Penetrating	37 (0.649)	19 (0.333)	1 (0.018)	21 (0.184)	0.94	1.02 (0.62-1.68)
Stricturing	113 (0.720)	38 (0.242)	6 (0.038)	50 (0.159)	0.37	0.86 (0.61-1.21)

IBD: Inflammatory bowel disease; UC: Ulcerative colitis; CD: Crohn’s disease.