Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis

Table 1 Characteristics of previously published association studies of MIF -173G > C in inflammatory bowel disease

Cohort	Sample size	Demographics				Ref.
		Race	mean ± SD	% male	IBD diagnosis
1	Cases: 111	Japanese	39 ± 14.2	52.3	UC	[18]
	Controls: 209		44 ± 18.4	58.4	NA
2	Cases: 221	Japanese	40.1 ± 14.0	46.2	UC	[15]
	Controls: 312		41.4 ± 18.1	50.3	NA
3	Cases: 99	Han Chinese	38.4 ± 10.6	61.6	CD (15); UC (84)	[13]
	Controls: 142		42.3 ± 11.6	64.1	NA
4	Cases: 623	Caucasian	-	48 (CD); 49.0 (UC)	CD (336); UC (287)	[16]
	Controls: 361		-	-	NA
5	Cases: 672	Caucasian	-	47.1 (CD); 43.0 (UC)	CD (325); UC (347)	[16]
	Controls: 526		-	-	NA
6	Cases: 99	Caucasian	-	-	41 (CD); 58 (UC)	[17]
	Controls: 123		-	-	NA
7	Cases: 198	Caucasian	39.5 ± 11.9	48.0	CD	[12]
	Controls: 159		44.1 ± 15.8	46.5	NA
8	Cases: 259	Caucasian	42.3 ± 10.2 (CD); 44.1 ± 15.3 (UC)	-	157 (CD), 102 (UC)	[14]
	Controls: 489		-	-	NA
9	Cases: 1234	Caucasian	-	47.2	CD	[32]
	Controls: 2112		-	51.0	NA
10	Cases: 590	Caucasian	21 ± 10.8	47.2	CD	[33,34]
	Controls: 678		-	49.3	NA
	Controls: 488		44.9 ± 11.2	41.2	NA
12	Cases: 139	Caucasian (Indian)	41.0 ± 14.11	59.3	139 (UC)	[19]1
	Controls: 176				NA

¹The study of Sivaram et al[19] was not included in the meta-analyses as study participants were neither East Asian, nor Northern European or American Caucasians. IBD: Inflammatory bowel disease; UC: Ulcerative colitis; CD: Crohn’s disease; NA: Not available.