Pain in chronic pancreatitis: Managing beyond the pancreatic duct

Figure 1 Schematic diagram representing neuroimmune mechanisms of pain in patients with chronic pancreatitis. The TrkA receptors (for nerve growth factor, NGF) are expressed on the sensory and sympathetic nerve fibres, p75 (for brain derived neurotropic factor, BDNF) on the perineurium and glial cell line-derived neurotrophic factor receptor α3 (GFRα3) (for Artemin) on the Schwann cell nuclei and intrapancreatic ganglia. The receptor expression is mediated by inflammation involving inflammatory cells and neural elements.