Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies

Table 2 Clinical trials with trastuzumab-based combination therapies

Setting, therapy line	ID	Phase	n	Treatment combined with trastuzumab	Primary EP	Status
Operable disease	NCT01196390	III	480	Carboplatin, paclitaxel, radical radiotherapy	PFS	Recruiting
	NCT01472029	II	53	5-FU, leucovorin, docetaxel, oxaliplatin	Rate of CR	Recruiting
	NCT01130337	II	45	Oxaliplatin, capecitabine	PFS	Active, not recruiting
Advanced first line	NCT01450696	III	400	Cisplatin, capecitabine	OS	Recruiting
	NCT01503983	II	51	Oxaliplatin, capecitabine	OS	Recruiting
	NCT01461057	II	30	Cisplatin, capecitabine, pertuzumab	Safety	Active, not recruiting
	NCT01396707	II	56	Oxaliplatin, capecitabine	RR	Recruiting
	NCT01364493	II	51	Oxaliplatin, capecitabine	RR	Recruiting
	NCT01359397	II	80	Docetaxel, oxaliplatin, capecitabine, bevacizumab	PFS	Recruiting
	NCT01228045	II	30	Cisplatin, S-1	RR	Unknown
	NCT01191697	II	36	Oxaliplatin, capecitabine, bevacizumab	RR	Recruiting
Advanced second line	NCT01402401	II	48	AUY922	RR	Terminated

ID, NCT identification (information available at http://clinicaltrials.gov, as accessed June 28, 2013). OS: Overall survival; PFS: Progression-free survival; 5-FU: 5-fluorouracil; RR: Response rate; CR: Complete response; PR: Partial response; NA: Not available.