Molecular targeted therapy for hepatocellular carcinoma: Current and future

doi:10.3748/wjg.v19.i37.6144

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Oct 7, 2013 (publication date) through Dec 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2013; 19(37): 6144-6155
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6144

Table 1 Molecular targets and therapeutic agents

Molecular targets	Therapeutic agents
VEGF/VEGFR	Sorafenib
	Bevacizumab
	Vatalanib (PTK787)
	Cediranib (AZD2171)
	Brivanib
	Sunitinib
	Linifanib (ABT869)
EGF/EGFR	Cetuximab
	Erlotinib
	Lapatinib
IGF/IGFR	OSI-906
	IMC-A12
	AVE1642
	BIIB022
Ras/Raf/MEK/ERK	Sorafenib
Ras/Raf/MEK/ERK	Selumetinib (AZD6244)
PI3K/Akt/mTOR	AZD8055
	Everolimus
	Sirolimus
	Temsirolimus
Wnt-β-catenin	PFK118-310
	PFK115-584
	CGP049090
MET	Tivanitib

EGF: Epidermal growth factor; EGFR: EGF receptor; ERK: Extracellular signal-regulated kinase; FGFR: Fibroblast growth factor receptor; IGFR: Insulin-like growth factor (IGF) receptor; VEGF: Vascular endothelial growth factor; VEGFR: VEGF receptor; mTOR: Mammalian target of rapamycin; MET: Met proto-oncogene.

Citation: Shin JW, Chung YH. Molecular targeted therapy for hepatocellular carcinoma: Current and future. World J Gastroenterol 2013; 19(37): 6144-6155
URL: https://www.wjgnet.com/1007-9327/full/v19/i37/6144.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i37.6144